Biological factors that impinge on Chagas disease drug development

Biological factors that impinge on Chagas disease drug development

Chagas disease is caused by infection with the insect-transmitted protozoan Trypanosoma cruzi, and is the most important parasitic infection in Latin America. The current drugs, benznidazole and nifurtimox, are characterized by limited efficacy and toxic side-effects, and treatment failures are frequently observed. The urgent need for new therapeutic approaches is being met by a combined effort...

Ergosterol biosynthesis and drug development for Chagas disease.

This article presents an overview of the currently available drugs nifurtimox (NFX) and benznidazole (BZN) used against Trypanosoma cruzi, the aetiological agent of Chagas disease; herein we discuss their limitations along with potential alternatives with a focus on ergosterol biosynthesis inhibitors (EBI). These compounds are currently the most advanced candidates for new anti-T. cruzi agents ...

Rheumatoid factors and Chagas' disease.

godial (1), which constitutes its chemical defense and is stored in the mantle. Thus the ability of a nudibranch to elaborate its chemical defense has been demonstrated. Dendrodoris limbata also synthesizes the mixture of sesquiterpenoid esters (2) found in the digestive glands. We believe that these esters should be regarded as products of further metabolism of polygodial as a result of a deto...

Climatic factors related to Chagas disease transmission.

Interactive media on Chagas Disease: Development and Content

An interactive media on Chagas disease was developed as an educational tool, on the context of the scientific research and dissemination actions of the National Institute of Structural Biotechnology and Medicinal Chemistry in Infectious Diseases (INBEQMeDI). Different computational resources were used either in terms of hardware and software. The media contains 13 videos that range from 30 seco...